My wife lost her job 3wks before our closing date on our first home. Is there any to salvage the loan?

It is best to try and find a job in the same field and/or industry to keep it consistent. If she finds one she will need to provide an offer letter and most likely will need at least one pay stub from the new employer prior to closing. Its possible for the loan to work even if the job is outside her field. A Loan Officer and underwriter can review the situation and see if it will work for you.

Finding a job in a similar position would be the easiest thing. I would not worry about any gaps in employment less then 3 months. I would expect that at least one pay stub from the new job would be required prior to closing.

If she can find another job in the same line for work and give a sound explanation for the gap in employment, you should be fine. As long as the income is enough and work in same line or industry...If she changes job types or industry, then that will be a problem...